*Pediatric and Liver Unit, Meyer Children's University Hospital of Florence, Italy †UCL Institute of Child Health, University College London, UK ‡Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt §Department of Women and Child Health, University of Padua ||PENTA Foundation, Padua, Italy ¶Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, University of Florida College of Medicine, Gainesville, FL.